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KMID : 1145120200180030265
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Asian Journal of Beauty and Cosmetology
2020 Volume.18 No. 3 p.265 ~ p.272
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Anti-aging Effect of Sulfuretin in UVA-irradiated Normal Human Epidermal Keratinocytes
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Shim Joong-Hyun
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Abstract
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Purpose: This study was carried out to investigate the epidermal moisturizing effects of sulfuretin on normal human epidermal keratinocytes (NHEKs).
Methods: Epidermal moisturizing effects of sulfuretin on NHEKs were assessed by quantitative real-time RT-PCR to monitor the expression of genes related to skin hydration, hyaluronic acid (HA)-ELISA assays to detect HA production, and cell viability assays.
Results: Sulfuretin increased the mRNA levels of the AQP3/HAS2/KRT1/KRT10 genes and HA production in NHEKs.
Conclusion: This study led to the identification of the epidermal moisturizing effects of sulfuretin. The results indicate that sulfuretin can be a potent cosmetic ingredient for skin moisturizing and antiaging products. However, further research is warranted regarding the use of sulfuretin to develop not only cosmetics but also medicines and food.
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KEYWORD
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Sulfuretin, Hyaluronic acid, AQP3, HAS2, Moisturizing
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